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xCT protein is key link in inhibiting pancreatic cancer growth and limiting mood disturbances

The xCT protein, which plays an important role as a transport molecule in the cell, could play a part in cancer treatment in the future, researchers have discovered. Their recent studies on mice show that targeting the protein can not only reduce tumor…

Large-scale animal study links brain pH changes to wide-ranging cognitive issues

The International Brain pH Project Consortium unveils groundbreaking findings in a large-scale animal model study, indicating altered brain pH and lactate levels as a transdiagnostic endophenotype in neuropsychiatric disorders with cognitive impairment…

Human brains are getting larger: That may be good news for dementia risk

A new study has found human brains are getting bigger. The increased size may lead to a brain reserve, potentially reducing the risk of dementia.

The aging brain: Protein mapping furnishes new insights

For the neurons in the brain to work smoothly and be able to process information, the central nervous system needs a strictly regulated environment. This is maintained by the blood-brain barrier, whereby specialized brain endothelial cells lining the i…

Movement disorder ALS and cognitive disorder FTLD show strong molecular overlaps, new study shows

Single-cell gene expression patterns in the brain motor and frontal cortex, and evidence from follow-up experiments, reveal many shared cellular and molecular similarities that could be targeted for potential treatment.

Early intervention after the first seizure may prevent long-term epilepsy and associated cognitive deficits

Only a very small percentage of neurons show changes after an epileptic seizure in mice, but these alterations can be permanent and trigger future seizures. An experimental treatment may prevent these long-term changes.

High-resolution brain created with 3D printer

A 3D-printed ‘brain phantom’ has been developed, which is modeled on the structure of brain fibers and can be imaged using a special variant of magnetic resonance imaging (dMRI). The scientific team has now shown in a study, these brain models can be u…

The power of neighbors: Neighboring synapses shape learning and memory

A researcher has developed a new model that provides a holistic view on how our brain manages to learn quickly and forms stable, long-lasting memories. Their study sheds light on the crucial role of interactions among neighboring contact sites of nerve…

Research offers hope for preventing post-COVID ‘brain fog’ by targeting brain’s blood vessels

Researchers have identified a mechanism that causes neurological problems in mice infected with SARS-CoV-2, the virus behind COVID-19. The researchers also found a treatment that helped prevent these changes.

Metformin during pregnancy affects the brain development in offspring mice, study finds

With the rise in gestational diabetes and metabolic disorders during pregnancy, metformin is also being prescribed more frequently. Although it is known that the oral antidiabetic agent can cross the placental barrier, the impacts on the brain developm…