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The nose-brain pathway: Exploring the role of trigeminal nerves in delivering intranasally administered antidepressant

Scientists have developed a novel concept of a nose-to-brain system for the clinical application of neuropeptides. They developed a derivative of glucagon-like peptide-2 and found that when administered intranasally, it is efficiently delivered through…

Autism research: Understanding reluctance to make eye contact with others

Using an innovative technology that enables imaging of two individuals during live and natural conditions, researchers have identified specific brain areas in the dorsal parietal region of the brain associated with the social symptomatology of autism.

Was I happy then? Our current feelings can interfere with memories of past well-being

Research suggests that one reason happiness can seem so elusive is that our current feelings can interfere with memories of our past well-being. An analysis of data from four longitudinal surveys to investigate how our current feelings influence our me…

OHSU scientists identify molecule that could help treat Parkinson’s

Researchers have discovered that the neurotransmitter adenosine effectively acts as a brake to dopamine, another well-known neurotransmitter involved in motor control. The discovery could immediately suggest new avenues of drug development to treat sym…

Rejuvenated immune cells can improve clearance of toxic waste from brain

Rejuvenating the immune cells that live in tissues surrounding the brain improves fluid flow and waste clearance from the brain — and may help treat or even prevent neurodegenerative diseases such as Alzheimer’s and Parkinson’s, according to a new stu…

Most detailed map of brain’s memory hub finds connectivity puzzle

An extremely detailed map of the communication links between the hippocampus — the brain’s memory control center — and the rest of the brain has been created. And it may change how we think about human memory.

New biomarker could help diagnose Alzheimer’s disease early

A definitive diagnosis of Alzheimer’s disease (AD) was once only possible after someone had died, but recent biomarker studies have led to the development of imaging and spinal fluid tests for those still living. However, the tests can only monitor sev…

Differences between brains of primates are small but significant, study shows

While the physical differences between humans and non-human primates are quite distinct, a new study reveals their brains may be remarkably similar. And yet, the smallest changes may make big differences in developmental and psychiatric disorders.

Mental landscapes: Seeing in 3D

Many thousands of retinal ganglion cells (RGCs) have to relay signals through the eye’s optic nerve via delicate projections, or axons, to precise locations on both sides of the brain that make visual sense of it all, especially to perceive depth. Some…

Neuronal mechanism involved in the learning of maternal behavior discovered

Various conditions such as postpartum depression or postpartum psychosis can lead to an alteration in maternal behavior and disrupt the mother-child bonding process. A research team has conducted a study in which they were able to identify the neuronal…