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Key signaling protein associated with addiction controls the actions of oxycodone in pain-free, chronic pain states

RGS9-2, a key signaling protein in the brain known to play a critical role in the development of addiction-related behaviors, acts as a positive modulator of oxycodone reward in both pain-free and chronic pain states

First cell culture of live adult human neurons shows potential of brain cell types

Studying brain disorders in people and developing drugs to treat them has been slowed by the inability to investigate single living cells from adult patients. In a first-of-its-kind study, researchers were able to grow adult human neurons donated from …

Scientists find sensor that makes synapses fast

Synapses, the connections between neurons, come in different flavors, depending on the chemical they use as transmitter. The type of synapses that use a signal transmitter called GABA stand out because of their speed and precision. But the secret behin…

Opioids produce analgesia via immune cells

Opioids are the most powerful painkillers. Researchers have now found that the analgesic effects of opioids are not exclusively mediated by opioid receptors in the brain, but can also be mediated via the activation of receptors in immune cells.

Mounting challenge to brain sex differences

A meta-analysis of human amygdala volumes reveals no significant difference between the sexes. The study strengthens the case for gender similarity in the human brain and psychological abilities.

Talking therapy changes the brain’s wiring, study reveals for first time

For the first time, research shows that cognitive behavior therapy (CBT) strengthens specific connections in the brains of people with psychosis, and that these stronger connections are associated with long-term reduction in symptoms and recovery eight…

Genetic discovery provides new insight into cognitive disorders

An international team of scientists has unlocked some of the genes responsible for cognitive ability.The findings bring scientists a step closer to developing new — and potentially better — treatments for cognitive disorders of the brain, such as sch…

Age-related GABA decline is associated with poor cognition

Diminishing levels of GABA, the primary inhibitory neurotransmitter in the brain, may play a role in cognitive decline as we age, according to a new study. The study shows an association between higher GABA concentrations in the frontal lobe, a brain r…

Children gain more weight when parents see them as ‘overweight’

Children whose parents considered them to be ‘overweight’ tended to gain more weight over the following decade compared with children whose parents thought they were a ‘normal’ weight, according to…

Treatment strategy provides mental health benefits to war trauma survivors

A study shows that a certain intervention called testimony therapy plus ceremony reduced symptoms of posttraumatic stress disorder, anxiety, and depression among Khmer Rouge torture survivors from…