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What are the health effects of chronic stress?

Stress is a biological response to demanding situations and a regular part of daily life. Stress becomes chronic when the body’s response goes on for a prolonged period. Chronic stress can have a range of health effects. Learn more about these effect…

How the grid cell system of the brain maps mental spaces

How exactly the grid cell system works in the human brain, and in particular with which temporal dynamics, has until now been speculation. A much-discussed possibility is that the signals from these cells create maps of ‘cognitive spaces’ in which huma…

Early changes to synapse gene regulation may cause Alzheimer’s disease

New research has revealed a role for splicing proteins in the pathology of Alzheimer’s disease. Increased phosphorylation of the SRRM2 protein, seen in AD mouse models and human patients, was found to block its transport to the nucleus. This reduced le…

Is sleeping too much bad for your brain?

The largest sleep study ever conducted concludes that both sleeping too little and too much negatively impacts cognitive ability, regardless of age.

Human brain cell transplant offers insights into neurological conditions

Scientists have created a ‘window’ into the brain, which enables researchers to watch in incredible detail how human brain cells develop and connect to each other in real time.

Thalamus wakes the brain during development

A new study suggests the thalamus controls the development of state dependency and continuity.

Questioning the link between pollution by magnetite particles and Alzheimer’s disease

A 2016 study showed that exposure to urban pollution involving magnetite particles played a role in the development of Alzheimer’s disease. It began from the hypothesis that magnetite particles would generate chemical reactions that could cause oxidati…

Cells in ‘little brain’ have distinctive metabolic needs

‘Knocking out’ an enzyme that regulates the flow of fuel into mitochondria specifically blocks the development of the mouse cerebellum more than the rest of the brain.

Recognizing the uniqueness of different individuals with schizophrenia

Individuals diagnosed with schizophrenia differ greatly from one another. Researchers have demonstrated that very few identical brain differences are shared amongst different patients. Therefore, insights based on research at the group level (i.e. in t…

Creating custom brains from the ground up

Scientists describe a new way to create customized mouse models for studying the brain. After killing off young brain cells, the developing forebrain can then be reconstituted from genetically engineered stem cells containing the specific genetic modif…