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Modulating rapamycin target protein promotes autophagy, lowering toxic Huntingtin protein

Recent failed clinical trials of a drug designed to clear the mutant Huntingtin protein that causes Huntington’s disease (HD) heightens the need for new approaches for the devastating, incurable, progressive neurodegenerative genetic disorder. Scientis…

Role of sleep-related brain activity in clearing toxic proteins and preventing Alzheimer’s disease

Evidence of sleep-dependent low-frequency (less than 0.1 Hz) global brain activity in the clearance of Alzheimer’s disease-related toxin buildup is presented in new research. This neuronal activity was more strongly linked with cerebrospinal fluid flow…

Scientists identify mechanism linking traumatic brain injury to neurodegenerative disease

Scientists have revealed a potential mechanism for how traumatic brain injury leads to neurodegenerative diseases.

Protecting the intellectual abilities of people at risk for psychosis

Psychotic disorders comes with a progressive decline in IQ. If current drug treatments are successful in containing psychotic symptoms, nothing can be done to prevent the deterioration of intellectual skills that leads to loss of autonomy. Researchers …

Scientists say active early learning shapes the adult brain

Through the Abecedarian Project, an early education, randomized controlled trial that has followed children since 1971, researchers have discovered an enhanced learning environment during the first five years of life shapes the brain in ways that are a…

New tool activates deep brain neurons by combining ultrasound, genetics

A team has developed a new brain stimulation technique using focused ultrasound that is able to turn specific types of neurons in the brain on and off and precisely control motor activity without surgical device implantation.

Same difference: Two halves of the hippocampus have different gene activity

A study of gene activity in the brain’s hippocampus has identified marked differences between the region’s anterior and posterior portions. The findings could shed light on a variety of brain disorders that involve the hippocampus and may eventually he…

Exoskeleton therapy improves mobility, cognition and brain connectivity in people with MS

A team of multiple sclerosis (MS) experts led a pilot randomized controlled trial of robotic-exoskeleton assisted exercise rehabilitation (REAER) effects on mobility, cognition, and brain connectivity in people with substantial MS-related disability. T…

Tiniest of moments proves key for baby’s healthy brain

The new findings identify a potential contributor to microcephaly, a birth defect in which the head is underdeveloped and abnormally small.

Alzheimer’s: Blood oxygen levels could explain why memory loss is an early symptom

Scientists have recorded blood oxygen levels in the hippocampus and provided experimental proof for why the area, commonly referred to as ‘the brain’s memory center’, is vulnerable to damage and degeneration, a precursor to Alzheimer’s disease.