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New microscopy method reaches deeper into the living brain

Researchers have developed a new technique that allows microscopic fluorescence imaging at four times the depth limit imposed by light diffusion. Fluorescence microscopy is often used to image molecular and cellular details of the brain in animal model…

Escape from oblivion: How the brain reboots after deep anesthesia

An innovative study uses the anesthetics propofol and isoflurane in humans to study the patterns of reemerging consciousness and cognitive function after anesthesia.

Brain tumors caused by normal neuron activity in mice predisposed to such tumors

Researchers have found that normal exposure to light can drive the formation and growth of optic nerve tumors in mice — and maybe people — with a genetic predisposition. Such tumors can lead to vision loss.

Non-hallucinogenic psychedelic analog reverses effects of stress in mouse study

A novel compound similar in structure to the psychedelic drug ibogaine, but lacking its toxic and hallucinogenic effects, has been found to rapidly reverse the effects of stress in mice. Researchers found that a single dose of tabernanthalog (TBG) can …

‘Rejuvenating’ the Alzheimer’s brain

Alzheimer’s disease is the main cause of dementia and current therapeutic strategies cannot prevent, slow down or cure the pathology. The disease is characterized by memory loss, caused by the degeneration and death of neuronal cells in several regions…

Low blood flow in the brain may be an early sign of Parkinson’s disease

Patients who suffer from REM sleep behavior disorder have altered blood flow in the brain, which can lead to a lack of oxygen in the brain tissue. In the long term, this may cause symptoms of Parkinson’s disease.

Press (re)play to remember – How the brain strengthens memories during sleep

While we sleep, the brain produces particular activation patterns. When two of these patterns – slow oscillations and sleep spindles – gear into each other, previous experiences are reactivated. The stronger the reactivation, the clearer will be our re…

Bile acids trigger satiety in the brain

Scientists have discovered a new role for bile acids: they curb appetite by entering the brain. Their findings provide new insights into the signals and mechanisms by which satiety is controlled and may have implications for treating obesity.

Step-closer to nasal spray drug delivery for Parkinson’s disease

Scientists have made significant progress in the development of a nasal spray treatment for patients with Parkinson’s disease.

Specialized inhibitory cluster gates plasticity in fear learning

Researchers have uncovered a new role for a distinct inhibitory cell cluster in the amygdala, acting to dynamically modulate synaptic connections during fear learning.